Rejuran Healer in Korea is the original polynucleotide (PN) formula in the Rejuran range, made by the Korean company Pharma Research and injected into the dermis to support skin quality: texture, elasticity, hydration and fine lines. It is a PN product, not PDRN, and comes as a water-based solution of roughly 20 mg per mL. A full-face session places the gel at about 200 to 300 tiny points after numbing cream. Small raised bumps for one to three days are normal, and bruising, redness and stinging can follow. Changes build gradually over a course rather than after one visit, and effects commonly last four to six months, though results vary from person to person.
PharmaResearch · RejuranGuide
Healer next to HB Plus and the i line
Healer is the plain version of the product: polynucleotide in water, with nothing added for numbing or volume. The two later lines were built on the same PN base. HB Plus mixes in hyaluronic acid and lidocaine, a local anesthetic, while the i line is made for the thin skin around the eyes.
That difference matters when you read a treatment plan. A doctor who writes only "Rejuran" has not told you which line goes where, so ask for the line to be named per area before the session starts.
| Line | What is in the syringe | Area it is meant for | Numbing approach |
|---|---|---|---|
| Rejuran Healer | PN in an aqueous solution | Cheeks, forehead, jawline, general face | Topical cream before injection |
| Rejuran HB Plus | PN with hyaluronic acid and lidocaine | Face where some added moisture is wanted | Cream, plus lidocaine inside the product |
| Rejuran i | PN formulated for thin skin | Under-eye and crow's feet area | Topical cream before injection |
Guide
What reviews of the research report
Titcomb's 2025 literature review in the Journal of Aesthetic Nursing pooled clinical studies on polynucleotides and found consistent gains in hydration, elasticity and general dermal condition, which the author linked to cell repair and collagen production. The same review pointed out that rules for these products are still thin in the United Kingdom, a reminder that standards differ by country.
A 2026 review by Khan and Hafeez in the Journal of Clinical Medicine looked at the under-eye area. Hyaluronic acid filler remained the standard tool for replacing lost volume, while PN showed steady improvement in elasticity, hydration and fine lines with a favorable safety profile. The authors also warned that studies varied widely in design and product, so firm conclusions are not yet possible.
- Healer works on skin quality, not on deep hollows or sagging.
- Volume loss under the eyes is usually a filler question, not a PN one.
Guide
A Rejuran Healer in Korea session, step by step
A visit usually starts with a look at the skin and agreement on the areas and the amount of product, then the face is cleansed. Numbing cream is left on until the skin is dull to touch, then wiped off before injection.
The gel goes in by fine needle, by an injector device, or a mix of both, at about 200 to 300 points across a full face. Each point raises a small bump that looks like a mosquito bite. A cooling or soothing step usually closes the visit.
- Ask which line is used on each area, and see the sealed box opened.
- Ask how many points and how much product each zone receives.
- Ask for aftercare in writing in a language you read well.
Guide
Side effects and who should hold off
The bumps are the expected part and usually flatten within one to three days. Bruising can appear where a needle met a small vessel and may take a week or more to fade. Stinging during injection, redness and mild swelling are common. Less often, people report lumps that last longer, infection at a puncture site or an allergic reaction.
Healer is not a fit for everyone. People who are pregnant or breastfeeding, have an active infection, acne flare or eczema on the area, or know of an allergy to fish-derived ingredients should raise it with the doctor before any injection. Anyone on blood thinners should expect more bruising and mention the medicine first.
Evidence
Research behind this page
- Hyaluronic Acid Fillers Versus Polynucleotides for Under-Eye RejuvenationJournal of Clinical Medicine · 2026 · doi:10.3390/jcm15134971
A review finding that hyaluronic acid filler stays the standard for under-eye volume, while polynucleotides give consistent gains in elasticity, hydration and fine lines with a favorable safety profile, within a mixed evidence base.
- A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotidesJournal of Aesthetic Nursing · 2025 · doi:10.12968/joan.2025.0009
A literature review reporting improved skin hydration, elasticity and dermal health with polynucleotides and highlighting gaps in UK regulation of these products.
FAQ
Questions about Rejuran in Gangnam
Which areas does Rejuran Healer in Seoul usually cover?
Healer is most often placed across the cheeks, forehead and jawline, where the aim is smoother texture and firmer-feeling skin. Clinics tend to switch to the i line for the under-eye zone because that skin is thinner. The neck and the backs of the hands can also be treated, with the amount set per area. Ask the doctor to show you on a mirror where each line will go before numbing starts.
Should under-eye hollows be treated with Healer or with a filler?
Hollows caused by lost volume usually call for hyaluronic acid filler, while thin, crepey skin is where PN fits. The 2026 review by Khan and Hafeez in the Journal of Clinical Medicine reached that split: filler for structure, polynucleotides for elasticity, hydration and fine lines. Some people need both, in separate steps. An examination of the area in good light usually shows which problem is the main one.
When can I wear makeup again after a Healer session?
Many clinics ask you to wait until the next day so the puncture points can close. Bumps may still be visible then, and light makeup is usually allowed over them once the skin is calm. Use clean brushes or fresh sponges for the first few days. Skip saunas, hard workouts and alcohol on treatment day, and follow the written aftercare from the clinic.
Do I need to mention a fish allergy before treatment?
Yes, tell the doctor about any fish or seafood allergy before the first injection. The polynucleotide in Healer is purified from salmon DNA, and a known allergy may make the treatment unsuitable. Mention other allergies, past reactions to fillers and any autoimmune condition as well. The doctor can then decide whether to proceed, test first or suggest a different option.
Do results show after one visit or only after a course?
Most people notice gradual change after a course rather than a single session, because PN works by supporting the skin over weeks. The doctor sets the number of sessions and the spacing from your skin and your travel plans. Effects commonly last four to six months, and results vary from person to person. Plan repeat visits honestly if you live abroad, since one session alone may show little.
How long can bruising last if it appears?
A bruise from a Healer injection often fades within about a week, though some take longer. It is more likely around the eyes, on thin skin, and in people taking blood thinners or certain supplements. Cold compresses on the first day can help. If a photo shoot, a wedding or a work event is close, leave a buffer of several days after the session.