Rejuran in Korea is an injectable polynucleotide (PN) skin booster that is placed into the dermis at many small points to improve texture, elasticity and fine lines over a course of sessions. It is made by Pharma Research, a Korean company, and is a PN product rather than PDRN. A session runs about an hour including roughly 30 minutes of numbing cream, while the injections themselves take a short part of that time. Raised bumps usually settle within one to three days, and flying home the same day is generally fine. Changes tend to show after a few weeks. Clinics price it per cc or per session before VAT, and this page compares clinics and their listed prices.
PharmaResearch · RejuranIs it for you?
Who Rejuran in Gangnam suits, and who should wait
A Rejuran treatment in Korea fits people whose main concern is skin quality: a dull or dehydrated surface, fine lines, rough texture, thin skin under the eyes or early laxity that shows as crepiness rather than drooping. It is often chosen by visitors who want a change that looks like better skin instead of a different face, and by those who already use lasers and want a booster alongside them.
It is not a lifting or volume treatment. Heavy jowls, deep folds and hollow temples will not change much with PN alone, and pigment spots need laser work. Anyone expecting a single session to transform the skin is likely to be disappointed, because the effect is gradual and builds over repeated visits.
Usually a good fit
- Dull, dehydrated or rough skin texture
- Fine lines and crepey skin around the eyes
- Shallow acne scarring and enlarged-looking pores
- Maintenance alongside laser or energy treatments
May be better to wait
- Pregnancy or breastfeeding
- Active acne, eczema or infection on the area
- Permanent filler or implants in the injection zone
- Marked sagging that needs lifting or surgery
Clinics in Gangnam
10 clinics for Rejuran in Gangnam
Every clinic below lists Rejuran among its treatments. Message a clinic directly.
1
2RE:BERRY Clinic Gangnam
3Aive Clinic
4Cleor Clinic Gangnam
5The Cell Skin Clinic
6Cellon Dermatology Clinic (Cheongdam)
7Medicube Clinic
8VandS Clinic Gangnam
9
10How it works
How a Rejuran session runs
Rejuran Healer contains purified polynucleotide chains from salmon at about 20 mg per mL. Injected into the dermis, the chains are thought to support the skin's repair environment and act as a scaffold for fibroblasts. A 2024 systematic review in the Journal of Cosmetic Dermatology by Lampridou and colleagues pooled nine studies with 219 patients and reported improvements in wrinkles, texture and elasticity in several of them, while rating the evidence as low to moderate quality.
The DNA-fragment idea has older roots. In 2003, Guizzardi and colleagues reported in Life Sciences that PDRN, a shorter DNA fraction, increased the growth of human bone-forming cells in the laboratory. That cell study did not test PN or skin, but it is part of the early work behind using nucleotide compounds for tissue repair.
Dosing in Korea is set by the amount of product, usually counted in cc or by syringe, and by the area treated. A full face commonly receives a few hundred micro-points. Delivery can be by needle, cannula or a needle-free jet device; in a 2024 split-face trial of 10 Korean subjects, Hong and colleagues found the jet side scored lower on pain and higher on global improvement than conventional needle injection.
Assessment
The doctor reviews skin type, concerns and medical history, chooses the product line and marks the areas. This takes about 10 to 15 minutes.
Numbing
Cleansing is followed by numbing cream left on for around 30 minutes. Some clinics add cooling during the injections.
Injection
Small amounts of PN are placed at evenly spaced points across each area by needle, cannula or jet device. This usually takes 15 to 30 minutes.
Soothing
A calming mask or cooling pack reduces redness for 10 to 20 minutes, and written aftercare is given before leaving.
Rejuran compared with other options
| Feature | Rejuran (PN) | Hyaluronic acid booster | PDLLA collagen booster |
|---|---|---|---|
| Main material | Polynucleotide chains | Non-crosslinked or lightly crosslinked hyaluronic acid | Poly-D,L-lactic acid particles |
| Main effect | Texture, elasticity, fine lines | Hydration and glow | Gradual collagen build-up and firmness |
| Placement | Dermis, many micro-points | Dermis, micro-droplets | Dermis or deeper, by needle or cannula |
| Sensation | Stinging, managed with numbing | Mild stinging | Pressure and stinging |
| Visible downtime | Bumps for one to three days | Bumps for about a day | Bumps and swelling for a few days |
At a glance
Rejuran facts
| Product and maker | Rejuran Healer, HB Plus and i, by Pharma Research (Korea) |
|---|---|
| Type | Injectable polynucleotide (PN) skin booster, not PDRN |
| Concentration | About 20 mg per mL in Rejuran Healer |
| Dose unit | Per cc or per syringe, by area |
| Numbing | Topical cream for around 30 minutes |
| Session length | About one hour including numbing |
| Visible downtime | Raised bumps for one to three days |
| Usual course | About three sessions, then maintenance |
| Flying home | Generally possible the same day |
Prices
Rejuran cost in Gangnam
Prices below come from the listed clinics' own price lists, before VAT. 10% VAT is added at payment.
Rejuran · 1 cc
Range across 3 listed clinics · approx. $131–$218₩180,000–₩300,000 + VATCompare clinicsRejuran · 2 cc
Range across 4 listed clinics · approx. $131–$291₩180,000–₩400,000 + VATCompare clinicsRejuran · 4 cc
Price at 1 listed clinic · approx. $436₩600,000 + VATCompare clinicsRecovery
What the days after look like
Raised bumps, redness and mild tenderness across the treated areas; skip makeup, saunas and alcohol.
Bumps flatten as the product spreads; light makeup is usually fine from the second day.
Any pinpoint bruises fade; gentle skincare and sunscreen continue, without strong acids or retinoids.
Texture and hydration changes become easier to notice, especially after the second session.
The effect gradually softens and many people plan a maintenance session.
Safety
Rejuran risks and limits
- Redness, swelling and raised bumps at injection points for a few days
- Pinpoint bruising, more likely under the eyes
- Lumps that persist longer than expected, or infection at a point
- Allergic reaction, including in people sensitive to fish proteins
- Rare vascular problems when product is placed near a vessel
- It does not lift sagging skin or replace lost volume
Evidence
Research behind this page
- The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic ReviewJournal of Cosmetic Dermatology · 2024 · Lampridou S, Bassett S, Cavallini M, Christopoulos G · doi:10.1111/jocd.16721
Systematic review of nine low- to moderate-quality studies covering 219 patients, reporting improvements in wrinkles, texture and elasticity with mostly mild, transient side effects.
- Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repairLife Sciences · 2003 · Guizzardi S, Galli C, Govoni P, Boratto R, Cattarini G, Martini D · doi:10.1016/s0024-3205(03)00547-2
Laboratory study showing that PDRN increased proliferation of human osteoblasts, early evidence for the tissue-repair role of DNA-fragment compounds.
- Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin RejuvenationJournal of Cosmetic Dermatology · 2024 · Hong J, Lee Y, Kim H, Park K · doi:10.1111/jocd.16595
Split-face trial in 10 Korean subjects in which needle-free jet delivery of PN gave lower pain scores and higher aesthetic improvement and satisfaction than needle injection.
FAQ
Questions about Rejuran in Gangnam
What is Rejuran made from?
Rejuran is made from polynucleotide chains purified from salmon DNA and suspended in a sterile solution. The purification removes proteins so that mainly the DNA fragments remain, at about 20 mg per mL in the Healer line. The HB Plus version adds hyaluronic acid and lidocaine. People with a known fish allergy should tell the doctor before any session. The product arrives as a clear liquid in a sealed vial or syringe.
How is the injection numbed, and how much does it sting?
Numbing cream is applied for around 30 minutes, which takes the edge off most of the stinging. Each point still produces a short pricking sensation, and areas near the nose and lips tend to feel sharper. Cooling during the injections and the lidocaine-containing HB Plus line both help. Tell the doctor if it becomes too uncomfortable so they can pause.
When do results from Rejuran in Korea start to show?
Most people notice smoother, more hydrated skin a few weeks after the first session, with clearer change after the second or third. The day after treatment the skin can look bumpy, which is not the result. Because PN works through the skin's own repair process, timing differs between people. Results vary from person to person. Photos taken in the same light before each session make progress easier to judge.
How long do the effects last?
The effect commonly lasts around four to six months after a completed course. It fades gradually rather than stopping suddenly. Age, sun exposure, smoking and skincare all influence how long the skin keeps its improved texture. Many people book one maintenance session every few months once the initial series is finished. Daily sunscreen is one of the simplest ways to protect the gain after treatment.
How far apart should sessions be spaced?
Sessions are usually spaced at least 7 to 10 days apart, and many doctors prefer a few weeks between visits. The gap lets swelling settle and the skin respond before more product is added. Visitors on a short trip often fit one session in Korea and plan the next on a later visit or with a doctor at home. Keep the dates and product amounts written down for any later doctor.
Is there a needle-free way to receive PN?
Yes, some clinics deliver PN with a needle-free jet device that pushes product into the skin with pressure. In a 2024 split-face trial in the Journal of Cosmetic Dermatology, Hong and colleagues found the jet side less painful and rated higher for improvement. The trial was small, so ask how depth and product amount compare before choosing it. Numbing cream is still commonly used with jet delivery.
Can men have this treatment too?
Yes, men commonly use PN injections for rough texture, enlarged-looking pores and shallow acne scars. Male facial skin is often thicker, so the doctor may adjust the amount or depth. Beard areas can bruise a little more and should not be shaved for a day after the session. The aftercare and recovery timeline are otherwise the same. Light exercise can resume after the first day.
How should I read a Rejuran Korea review I find online?
Treat individual online accounts as one person's experience, not as a prediction of your own result. Skin type, product line, amount used and number of sessions all differ between people. A more reliable check is what the clinic tells you directly: which product it uses, how much goes into each area and what side effects to expect. Photos without filters or edits, taken in daylight, give a fairer picture.
Do clinics in Seoul use the same product sold in other countries?
The maker is Korean, so clinics in Seoul use the original domestic product, and the same brand is exported to many countries. Packaging and product line names can differ slightly between markets. Ask to see the sealed box before treatment and check the maker's name, lot number and expiry date on the label. Photographing the label keeps a record for any later appointment.
Is it safe to have PN injections while pregnant?
No, PN injections are postponed during pregnancy and breastfeeding because safety has not been studied in these groups. The same applies to people with active skin infections, uncontrolled autoimmune disease or a fish protein allergy. Share your full medical history and current medicines at the consultation so the doctor can decide whether treatment is appropriate. If in doubt, wait until after breastfeeding has ended.